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Information × Registration Number 0210U003490, 0107U004943 , R & D reports Title Development of approaches to cells therapy of heart pathologies popup.stage_title Head Lyubov L. Lukash, Доктор біологічних наук Registration Date 08-02-2010 Organization Institute of Molecular Biology and Genetics popup.description2 By using transgenic and conditional knock-out mice was shown than delay of intracellular adhesion at early embryogenesis has a critical role not only for cardiogenesis but for embryonic development. We founded than ablation of N-cadherin leads to delays of embryonic development and cardiovascular system formation and were lethality at early terms of gestation. Missing of ?E-Catenin or ?-Catenin did not lead to morphological defects of heart-vascular systems forming during embryogenesis, but we reviled the partial lethality of embryos with ablation of ?-Catenin gene in the middle of embryo development. The partial lethality of new-born mice with ?-Catenin deletion was detected. Product Description popup.authors Коломіець Юрій Михайлович Костецький Ігор Євгенович Мацевич Лариса Леонідівна Півень Оксана Олександрівна Яцишина Анна Петрівна popup.nrat_date 2020-04-02 Close