Search academic texts

Information × Registration Number 0210U003609, 0107U007749 , R & D reports Title Construction of effective stabile overproducer of vitamin B2 based on Candida famata yeast popup.stage_title Head Dmytruk Kostyantyn Vasylovych, Registration Date 12-02-2010 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 The method of positive selection for cloning of genes responsible for stability of industrial riboflavin producing strain dep8 (АТСС 20849) was developed. The gene SEF1 involved in positive regulation of riboflavin sinthesis in Candida famata yeast was identified. Introduction of additional copy of SEF1 3-4-folds stimulates riboflavin productivity (up to 80 mg of riboflavin / g of yeast) and 3-4-folds stabilizes the strain on the feature of "riboflavin oversynthesis". Constructed C. famata IMB Y-5033 strain could be used for more efficient industrial riboflavin production due to increased flavinogenic activity and stability. Product Description popup.authors Іщук Олена Петрівна Вороновський Андрій Ярославович Сибірний Андрій Андрійович Убийвовк Віра Михайлівна popup.nrat_date 2020-04-02 Close