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Information × Registration Number 0210U003642, 0107U000904 , R & D reports Title Investigate the mechanisms of treatment-and-preventive effects of the phitoadaptogens at dental pathology. popup.stage_title Head Levitsky Anatoly Pavlovich, Registration Date 17-02-2010 Organization Odessa Scientific Research Institute of Stomatology popup.description2 The subject of investigation is the dentifrice waters with bioflavonoids ("Biodent-4", "Extravin-Denta", "Tatyana", "Apelsinovyj", "Greipfrutovyj", "Mandarinovyj", the preparation "Calcicor", PF-4 (extracts from germs of wheat, oats, rye, milfoil), the rats of Vistar line, patients with dental pathology. The purpose of investigation is the study of the mechanisms of the influence of phytoadaptogens in vitro and at experimental pathology, as well as the investigation of their clinical effectiveness. The methods of investigation are technological, experimental, biochemical and statistical. Devices: spectrophotometer UV mini-1240 Shimadzu, ionometer рН-150М, laboratory scales VLR-200, centrifuge RS-6, chromatograph Shimadzu. The scientific novelty. The formulations of the new preparations of phytoadaptogens are substantiated. The anti-inflammatory, caries- and periodontioprotective effect of the elaborated preparations was revealed to be achieved due to the antioxidant, antiphospholipase, antiprotease, antitoxic and antimicrobe characteristics of bioflavonoids, they contain. The totality of the biological characteristics of bioflavonoids, and preparations correspondingly, favors the growth of nonspecific resistance of the organism under the conditions of pathology and increases considerably the effectiveness of dental treatment. The practical value. The technologies of the obtaining of the dentifrice waters "Biodent-4" (RCU 013903778. 001-92/7-2008), "Extravin-Denta" (RC U 24.5-34737476 - 002: 2008), "Tatyana" (RC U 013903778.001-92/6-2007), "Apelsinovyj" (RC U 013903778-001-92/5-2003), "Greipfrutovyj" (RC U 013903778.001-92/2-2007), "Mandarinovyj" (RC U 013903778.001-92/1-2007), the preparation "Calcicor" in pills (TU U 15.8-13903778-039:2007, conclusion № 05.03.02-06/40697 from 10.08.2007 DKPP 15.89.20), were worked out. There were 10 patents received. The experimentally found caries- and periodontoprotective, anti-inflammatory effects allow recommendation the elaborated preparations of phytoadaptogens for practical dentistry. Product Description popup.authors Баришева Інна Анатоліївна Зеленіна Юлія Вікторівна Кнава Ольга Едуардівна Крисюн Ірина Ігорівна Міх Юлія Сергіївна Макаренко Ольга Анатоліїна Мезінова Людмила Григорівна Платовська Ірина Вікторівна Полуектова Людмила Валентинівна Розсаханова Лариса Миколаївна Селіванська Ірина Олександрівна Ходаков Ігор Володимирович popup.nrat_date 2020-04-02 Close