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Information × Registration Number 0210U003771, 0107U002582 , R & D reports Title Regenerations properties of bone marrow stem cells of at the damage of tissue at the mise of different age. popup.stage_title Head Butenko Gennadij Mikhailovych, Registration Date 04-03-2010 Organization State Institution "Institute of Gerontology AMS Ukraine" popup.description2 The object of research- mice lines CBА/Са age 3 mo and 20 mo. The purpose of research - to study features of influence of transplantation hematopoietic stem cells of a bone brain and fetal liver on function immune systems at animals different age. Research methods - definition of amount АPC in spleen, blast-transformation of splenocytes under influence mitogens PHA and LPS, agglutinins and haemolysins in serum, phagocyte activity of macrophages, a subpopulation of cells in bone marrow, thymus, spleens, cells-precursors of a bone marrow (the CFU-GM, the CFU-F). The equipment - X-ray appliance "РУM-17", microscope, flow cytometer, thermostat. Determine ways and mechanisms migrate and differentiations stem cells of a bone marrow in the damaged tissue at their transplantation in organisms of different age. Opportunities of therapeutic use stem cells of a bone marrow with the purpose of regeneration and a reparation of the damaged tissue and bodies during the different age periods. It is shown to feature of influence stem cells of a bone brain on parameters of immune system in conditions of radiating damage and in intact an organism of different age. Obtained data allow to estimate optimum conditions of allocation and transplantation stem cells with the purpose of effective regenerative influence on immune system that is one of key problems of regenerative medicine and transplantlogy. Product Description popup.authors Кирик Віталій Михайлович Лабунець Ірина Федорівна Подяченко Олена Вікторівна Родніченко Анжела Євгенівна Школьнікова Любов Іванівна popup.nrat_date 2020-04-02 Close