1 documents found
Information × Registration Number 0210U003842, 0109U006746 , R & D reports Title Substituted amides of the triazinyl-propancarbonic acid as potent inhibitors of human mycosis and mycotoxicosis : toxicopharmacological investigation and search of medicinal forms popup.stage_title Head Shved A.D., Registration Date 17-03-2010 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 More than 30 triazinyl-propancarbonic acid amides (PCA) were synthesized and characterized, among them the highly effective inhibitors of yeast-like fungi Candida albicans were found. Fungicide activity of a few substances proved to be more effective than that of the commercial preparation difluсan. The in silico investigation of the synthesized compounds involved allowed to envisage the possible mechanism of their action concerning the inhibition of two cellular targets, C. albicans DNA-dependent RNA polymerase and dihydrofolate reductase. Based on three substances of the PCA the ointment compositions and solid dosage forms for local treatment of candidiasis were proposed. Product Description popup.authors Алєксєєва Інна Володимирівна Костіна Валентина Григорівна Лисенко Надія Антонівна Пальчиковська Лариса Гнатівна Платлнов Максим Олегович Усенко Любов Семенівна Швед Анатолій Давидович popup.nrat_date 2020-04-02 Close
R & D report
Substituted amides of the triazinyl-propancarbonic acid as potent inhibitors of human mycosis and mycotoxicosis : toxicopharmacological investigation and search of medicinal forms
Head: Shved A.D.. Substituted amides of the triazinyl-propancarbonic acid as potent inhibitors of human mycosis and mycotoxicosis : toxicopharmacological investigation and search of medicinal forms. (popup.stage: ). Institute of Molecular Biology and Genetics of NASU. № 0210U003842
1 documents found

Updated: 2026-03-28


Роздрукувати цю сторінку