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Information × Registration Number 0210U004195, 0107U005548 , R & D reports Title The assessment of targets for alcaloid-ethyleneimines for grounding their efficient use popup.stage_title Head Philchenkov Oleksii Oleksiiovych, Registration Date 19-03-2010 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Acute and chronic toxicity of amitosinoberamide was studied in experimental animals. In single intraperitoneal administration LD50 of amitosinoberamide is 300 mg/kg in rats, 148 mg/kg in mice, and 130 mg/kg for hamsters. The acute toxicity of amitosinoberamide is manifested in sympoms characreristic of acute poisonong with natural and modified berberibe compounds. The effects of amitosinoberamide in normal tissues is different from that of alkylating agents. When chronic toxicity was assessed, LD50 of amitosinoberamide in rats amounted to 90 mg/kg suggecting the cumulative effects of the substance. In general, amitosinoberamide is less toxic than berberine and thyophosphamide while its efficacy, in particular, in human malignant lymphoid cells is not inferior. The mechanisms of pharmacologic activity of amitosinoberamide are predominantly associated with the alkaloid moiety of the molecule. Amitosinoberamide is devoid of mutagenic activity in Ames test. Amitosinoberamide is not teratogenic in Wistar rats. Product Description popup.authors Заїка Леонід Андрійович Завелевич Михайло Петрович Потопальська Юлія Анатоліївна Потопальський Анатолій Іванович Фильченков Алексей Алексеевич popup.nrat_date 2020-04-02 Close