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Information × Registration Number 0210U004415, 0106U001416 , R & D reports Title Studying of "structure-activity" relationships in the 1,4-benzdiasepine and 1,2-dihydroquinoline derivatives, their pharmacodinamics, pharmacokinetics, phisics-chemical properties and bioavailability after various methods of administration popup.stage_title Head Andronati Sergiy Andreevich, Registration Date 06-12-2010 Organization Odessa I.I.Mechnikov National University, Research Institute "Astronomical Observatory" popup.description2 Was synthesis new 1,4-benzdiasepine and 1,2-dihydroquinoline derivatives. Was study anticonvulsant activity these compaunds by the complex of physics-chemical and pharmacology methods. Was determined structure-functional rules of demonstration of this activity. Was determined of pharmacology properties of 3-hydroxybenzdiasepine esters. Was shown that basic methabolite is 3-hydroxybenzdiasepine. Was shown big affinity to brain tissues of these esters. Results of research was apply to learning process of educational institution of Ukraine. Product Description popup.authors Александрова О.А. Бойко Ю.О. Грищук Л.В. Кириченко І.М. Кравченко І.А. Радаєва І.М. Сівко Г.І. Турянська Г.М. Федорова О.А. popup.nrat_date 2020-04-02 Close