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Information × Registration Number 0210U006826, 0107U010165 , R & D reports Title To learn the efficiency of usage of the cell-tissues technologies for renovating of bone tissue damaged in the result of the influence by factors of different (non-infectious) genesis. popup.stage_title Head Vozianov A.F., Kazakov V.N., Registration Date 17-12-2010 Organization Donetsk National Medical University after named Gorky popup.description2 Purpose: To improve efficiency of treatment of slowly consolidating breaks and defects of bones of extremities on the basis of study of some mechanisms of остеорепарации and its optimizations by the use of the cultivated мезенхимальных barrel cages. In the report of приведенны данніе on the study of influence of низко- and high-energy traumas on the flow of осторепаративных processes and state of cellular sources of остеорепарации. It is set on the basis of experimental researches of in vitro and in vivo, that the cellular sources of остеорепарации, under act of injuring to the agent, suffer considerable changes which result in морфофункциональным violations from the side of these cages. The last have a display as violations of пролиферативных capabilities and changes to cellular morphology during cultivation, and also in the loss of periosteum cages by soy of остеогенной determinedness. Also in the conditions of in vitro general membrane antigens and general spectrum of цитокинов which are producted некомитированными and комитированными on a остеогенному way by a мезенхимальными barrel to the cages are studied (MSK). It is set on the basis of гистоморфологических researches, that in area of transplantation of MSK at first there are processes which are directed on ремоделирование of некротизированных bone fragments, whereupon there is a start of processes of остеогенеза. Depending on terms which are created in transplantation (presence or absence of immobilization), MSK can form both bone and cartilaginous to fabric. It is set on the basis of experimental researches of in vitro and in vivo, that most inductive properties are possessed by биоимплант of "Osteomatriks". Presence of inductive properties in гидроксиапатита, ceramic glass and bioimplant of "Tutoplast" extremely doubtful. Also in the conditions of in vitro морфофункциональные changes which take place with MSK during their остеогенной induction by Dexamethazonum are studied. It is set that since cages get a остеогенную orientation, their пролиферативная activity sharply goes down quite disappears and then. On the basis of study of products of alkaline фосфатазы developed the прегениторными cages of periosteum and patented method of "biological" остеогенной induction of MSK. Advantage of this method is that cages after their остеогенной induction save пролиферативную activity. On the basis of study of inductive properties of transmitters, development of "biological" остеогенной induction of MSK, developed technology of creation of three-dimensional to the остеопрогениторного transplant. On the basis of проведенних of experimental researches technology of transplantation of cultivated MSK and остеогенных tissue equivalents was developed at the damages of bone fabric of different genesis. Testimonies and contra-indications are certain to application of cultivated MSK and остеогенных tissue equivalents at the damages of bone fabric of different genesis. Certainly, that clinical efficiency of application of cultivated MSK and остеогенных tissue equivalents at the damages of bone fabric of different genesis is 97,3%. Product Description popup.authors Буше В.В. Вакуленко В.М. Гребенюк А.М. Гринь В.К. Канзюба А.І. Канзюба М.А. Климовицький В.Г. Климовицький Ф.В. Коваленко О.В. Кривенко С.Н. Магомедов Ю.А. Мисік Н.В. Оберемко А.В. Оксимець В.М. Попандоауло А.Г. popup.nrat_date 2020-04-02 Close