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Information × Registration Number 0210U006880, 0109U001281 , R & D reports Title Determine of a basic regularity of a sepsis development by thermal trauma popup.stage_title Head Jernov Olexandr Andriyovich, Registration Date 20-12-2010 Organization State Institution "Institute of Haematology and Transfusiology AMS Ukraine" popup.description2 1.The object of research - 30 patients with profound and extensive burns from 10% to 60% of body surface who underwent early surgical treatment. 2. Мethods : clinical, haematological, biochemical, cytochemical,immunological,microbiological. Burn, more than 30% body surface burn, miscellaneous causes of morpho-functional abnormalities in the internal organs and body systems affected, decreased activity of factors of natural resistance to the development of endotoxicoses, secondary immune deficiency with increased levels of IL-1, FNP, IL-10, nitric oxide and gomotsystein. These changes play a major role in the development of sepsis and multiple organ dysfunction in thermal injuries. The development of sepsis accompanied by the emergence of autoimmune reactions due to association products of tissue destruction and microbial toxins. Using an early surgical treatment can improve during the burn disease by reducing the number of complications from the main internal systems of the body, optimizing the microbial landscape of burn wounds and reduce the risk of infection generelisation, prevention of severe burn sepsis with multiple organ failure. Medicine. Product Description popup.authors Боярська Г.М. Жернов А.О. Коваленко О.М. Козинець Г.П. Мірошниченко З.М. Осадча О.І. Циганков В.П. popup.nrat_date 2020-04-02 Close