Search academic texts

Information × Registration Number 0210U006963, 0110U003715 , R & D reports Title Supramolecular systems in chemistry and biology. Mechanisms of comlexation of macrocycles with enzymes. 1 stageInhibition of phosphatases by bisphosphonate derivatives of calixarenes. popup.stage_title Head Vovk A., Registration Date 29-12-2010 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 Efficiency of human protein tyrosine phosphatase 1В inhibition by ?-ketophosphonic and 1-hydroxy methylenebisphosphonic acids on a macrocyclic platform has been established. On example of PTP1B, PTP? and LAR PTP selectivity of influence of these compounds has been investigated. The received results can have practical value for search of protein tyrosine phosphatase 1В inhibitors as a potential therapeutic target for treatment of 2 type diabetes. Product Description popup.authors В.Ю. Танчук popup.nrat_date 2020-04-02 Close