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Information × Registration Number 0210U007255, 0105U008878 , R & D reports Title Complex experimental study of the pharmacological activity of new derivatives of germanium containing compounds with bioligands popup.stage_title Head Kresyun Valentin Iosephovich, Registration Date 23-11-2010 Organization Odessa state medical university popup.description2 For the first time it was established the action of new oxyethylendiphosphonates on behaviour activity of intact animals and during experimental neuropathologic syndroms. Studied compounds, depending on their chemical structure, possess tranquilizing, adaptative, anticonvulsant and others neurotropic effects. Germamid has the most expressed anticonvulsant action: the mechanism of germamid's action is established. At different experimental models of parkinsonic syndrome the efficiency of germacord is set. On a background of the toxic damage of liver a hepatoprotective action of new compounds is revealed. In addition, the mechanism of action of new compounds has been studied. According to force of membranoprotective effect new compounds are disposed as following: nicogerm > germamid > germacord. Advantage. The neurotropic and hepatoprotective effects of new biological active compounds from the oxyethylendiphosphonate derivatives are first explored. For the first time it was established mechanisms of action of the most active compounds. . Product Description popup.authors Андронов Дмитро Юрійович Антоненко Катерина Олексіївна Антоненко Петро Борисович Відавська Ганна Георгієвна Волошенков Дмитро Борисович Годован Владлена Володимирівна Даніленко Анатолій Іванович Кресюн Валентин Йосипович Мніх Валентина Петрівна Погоріла Ірина Вікторівна Тимчишин Олег Львович Чихічина Людмила Дмитрівна Шандра Олексій Антонович Шемонаєва Катерина Федорівна popup.nrat_date 2020-04-02 Close