Search academic texts

Information × Registration Number 0210U007415, 0105U005339 , R & D reports Title Investigation of physico-chemical mechanisms of DNA point spontaneous mutations caused by its prototropic tautimerism popup.stage_title Head Hovorun Dmytro Mykolayovych, Registration Date 28-12-2010 Organization Institute of Molecular Biology and Genetics popup.description2 Novel physico-chemical models of the spontaneous and induced by the chemical mutagens transitions which can adequatly explain molecular biological experiments were elaborated and analyzed. Mechanisms of transitions arising based on the base tautomerization through proton transfer within wobble mispairs and Watson-Crick base pairs in DNA. Proposed mechanisms of the spontaneous transitions arising were used for explaining mechanism of the induced by the mutagenic nucleobases analogues - namely halogen-deriatives of Urа, 2AmPur and DCyt. The increasing of the rate of induced mutations is directly connected with activation barrier decreasing and population of the mispairs involving rare tautomers increasing. Product Description popup.authors Букатий О.М. Говорун Д.М. Горб Л.Г. Данілов В.І. Жураківський Р.О. Зарудна М.І. Коломієць І.М. Потягайло А.Л. Самійленко С.П. Степанюгін А.В. Черепенко О.Й. Юренко Є.П. popup.nrat_date 2020-04-02 Close