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Information × Registration Number 0210U007473, 0105U005340 , R & D reports Title Features of functioning and plurality of forms of the eukaryotic translation elongation factor 1 popup.stage_title Head El'skaya A.V.; Negrutskii B.S., Registration Date 30-12-2010 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Using list of biophisycal and bioinformatic methods for the first time we determined, in spite of eEF1A1 and eEF1A2 isofoms have a 98% aminoacid sequence homology, they have different three dimensional configuration in solution. A1 isoform has "extended" conformation while A2 isoform is more globular protein. It was suggested theoretical explanation of these isofoms existence in tissues of higher eukaryots. It was predicted that differences of three dimensional organization of similar proteins can influence on protei-protein interactions in tumor cells, i.e. it is one of the factors which influence on oncogenic feature of A2 isoform. Product Description popup.authors Будкевич Т.В. Верем 'єва М.В. Власенко Д.О. Ладохін О.С. Лукаш Т.О. Марценюк О.П. Новосильна О.В. Оболенська М.Ю. Перепелюк М.М. Петрушенко З.М Погрібна А.П. Порубльова Л.В. Слончак А.М. Теплюк Н.М. Токовенко Б.Т. Футерник П.В. Шалак В.Ф. popup.nrat_date 2020-04-02 Close