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Information × Registration Number 0210U007808, 0109U006063 , R & D reports Title Utilization of localized surface plasmon resonance effect for the development of sensor systems based on gold nanostructure arrays. popup.stage_title Head Lopatynskyi Andrii Mykolayovych, Registration Date 22-12-2010 Organization Institute of Semiconductor Physics of National Academy of Sciences of Ukrain popup.description2 Computer modeling of properties of light extinction, scattering and absorption by nanostructures in the form of gold spherical nanoparticles was carried out to investigate the sensitivity and response trends of such sensor system upon the formation of biomolecular cover on the surface of the nanoparticle, which was immersed in water. It was shown that the spherical Au nanoparticles are sensitive to large overlayer thicknesses; however, the shift of the localized surface plasmon resonance peak (LSPR response) in the light extinction spectrum for thicker overlayer grows slower with an increase in overlayer thickness compared to the same increase in that of a thinner overlayer. It was revealed that the upper limit of sensitivity to biomolecular cover is smaller but comparable to that of the conventional surface plasmon resonance (SPR) technique at equal nanoparticle diameter and gold film thickness in SPR. It was demonstrated that LSPR response for small nanoparticles (with a radius up to 5 nm) could be positive or negative depending on the nanoparticle size and biomolecular cover thickness. It was also found out that contribution of scattering into total extinction depends on the ratio between nanoparticle and overlayer sizes, namely, scattering increases and could lead to negative LSPR response upon the increase of nanoparticle radius and cover thickness. Equations for the number of globular biomolecules and their surface concentration for saturated biomolecular monolayer on the surface of the nanoparticle were derived for further use in description of biomolecular cover by means of effective medium theory. Samples of ordered gold nanoparticle arrays (NPAs) of different morphology were obtained by means of nanoimprint lithography (NIL) technology and electret template method. Structural properties of ordered NPAs were studied by means of atomic force microscopy technique. Spectral properties of obtained NPAs in air were investigated and distinct plasmon peak in the NPA light extinction spectrum was demonstrated. Prototype of portable biosensor based on obtained NPAs was created. NIL-produced NPAs were used for the detection of biospecific reaction between bovine serum albumin (BSA) and anti-BSA immunoglobulin; limit of detection of anti-BSA equal to 20 ng/ml was achieved. Product Description popup.authors Лопатинський Андрій Миколайович popup.nrat_date 2020-04-02 Close