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Information × Registration Number 0211U000139, 0108U001057 , R & D reports Title Pathogenic reason and elaboration of theraputical prophylactic and rehabilitation measures for pregnant with valvular heart disease directed on decreasing of maternal and perinatal mortality popup.stage_title Head Avramenko T.V., Gutman L.B., Registration Date 19-01-2011 Organization State enterprise "Institute of Pediatrics, Obstetrics and Gynaecology Academy of Medical Sciences of Ukraine" popup.description2 Found that in women with acquired heart defects has been a violation of endothelial function, changes in the eicosanoids and the hemostatic system, which show reduced exercise tolerance, worsening quality of life and psychological status, high frequency of complications of pregnancy and childbirth, a violation of the state of the fetus and newborn . Immunohistochemical study in placentas showed a significant increase in the intensity and prevalence of endothelin-1 on the background of expressive expression of mesenchymal factor Vimentin, and PCNA and SD31. An experiment was held on the effect of antirheumatic drugs and anesthetics on contractile function and the tone of the uterus. The additional risk factors have been marked, which include indicators of the endothelial function of prostanoids and developed an algorithm for prediction of obstetric and perinatal complications. A scheme of treatment and preventive measures, which, besides anti-inflammatory drugs, includes exercise, mental relaxation and spa rehabilitation, proved its effectiveness. Scientific novelty: the first time revealed new links influence endothelial dysfunction, reduced myocardial reserve on the development of complications in the mother and fetus, and on this basis new methods of forecasting, therapy and rehabilitation and perinatal care in pregnancy in women with acquired heart disease. According to studies published chapters in monographs, reference books, textbooks, 3 articles, 3 abstracts, filed an application for utility model, made 3 of the report. Product Description popup.authors Єрмолова Г.С. Єщенко О.І. Владимиров О.А., Тофан Н.І. Геревич Г.Й. Герман О.Б., Янюта О.С. Гудименко А.А. Коломійченко Т.В. Кульчицький С.К. Мініна О.О. Малиновська К.С. Марухно В.В. Мелліна І.М. Нікішіна В. Савченко С.Є. Сопко Я.О., Головченко Л.В. Стрижак С.К. Тищенко В.К. Тутченко Л.І. Ципкун А.Г. Чернишов В. popup.nrat_date 2020-04-02 Close