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Information × Registration Number 0211U000190, 0108U000209 , R & D reports Title To research normality actions of save animals cells homeostasis and organisms for protective antiviral agents by viral infections popup.stage_title Head Кlestova Zinaida Sergeevna, Доктор ветеринарних наук Registration Date 25-01-2011 Organization The Institute of veterinary medicine of Ukrainian Academy of Agrarian Sciences popup.description2 Researches were directed to receiption and optimization of the model systems for the study of anti-virus means in vitro. Test-model viruses (equine herpesvirus of the first type and bovine rotavirus) are adapted to the continious cell cultures SKEV, ВНК-21, CTP and Vero with sufficient infectious activity and expressed CPE the for investigation of inhibitive virus activity of given means. The optimal parameters of sterilization of solutions of anti-virus means are established. It is 0,5 atm. during 20 min for all means MTD of all testable means: synthetic derivatives of porphirines, tylorone, acyclovire, amisone, indomethacin and them are defined Determined reliable anti-virus activity of all investigated means in vitro system The sharp toxicness of all testable means is studied in vivo system on laboratory animals. Correlation of toxicness data is set in the systems of in vitro and in vivo. The methods of preclinical control and determination of anti-virus properties of coompounds are elaborated and compatible in the system of in vitro. A clinical-epizootological inspection of calfs is conducted on dairy farms in Zhytomyr region. Identified etiologic agents that cause gastrointestinal infections in calves (serological group of pathogenic E.coli - 66,4% of the samples, bovine rotavirus - in 30,5% of samples, salmonella - in 3,1% of samples). Coliinfection as monoinfection detected in 59,6% of cases of rotavirus disease - in 16.5% of cases and their associated course - in 34,6% of cases. The set difference is in the flow of the associated gastroenteric infections of calfs, got from cows-mothers with different serum status in relation to a leucosis. Serum typification of pathogenic E.coli is conducted. Proved efficiency and worked out the chart of application of preparation of "Combipheron" at a flow associated coli- and rotavirus infections of calfs to 20-daily age in groups, got from RID-negative and RID-positive on a leucosis cows. Set reduction of calfs treatment term with preparation "Combipheron" on the average on a 3 days (as compared to other, by the traditional method of treatment) at the associated flow of coli-rotavirus infection of calfs. At economic efficiency 39,8 hrn. are on a 1 hryvnia. Product Description popup.authors Бездітко Людмила Володимирівна Зоз Ольга Степанівна Марченко Марина Іванівна popup.nrat_date 2020-04-02 Close