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Information × Registration Number 0211U000264, 0108U002525 , R & D reports Title Biotechnology of Annelides; Study of Annelides bioactive substrances and its immune modulating effects by nev immunogenesis methods. popup.stage_title Head Frolov Olexcandr Kirilovich, Registration Date 27-01-2011 Organization Zaporozhye National University popup.description2 The overall objective of the research work: the development and implementation of advanced kolchetsov with the study of biologically active substances developed by the newest immunogeneznymi methods. Results: the results of scientific work was discovered by a strict epitheliotropic endosymbiont leech intestinal bacterium Aeromonas hydrophila. Her bakfiltrat had apoptotichny effect on human blood leukocytes, and exogenous biologically active substances of the culture water, which is formed by biotechnology medicinal leech - suppressed saprophytic pigment and conditionally pathogenic flora. Similarly to bakfiltratu Aeromonas hydrophila was the action of the salt extract of red Californian worm in white blood cells of rats under conditions in vitro. Endogenous biologically active substances of the medicinal leech were immunomodulation effect in patients with human girudoterapii, which consisted in the suppression of redundant functions of initiating immunegenesis helper lymphocyte subpopulations CD4, CD25 and adequate stimulation of suppressor subpopulations of CD8, CD16. In the experiment on a group of goats has shown effectiveness girudoterapii in enhancing productivity and fertility of animals. Faunal monitoring of population dynamics in the waters of the medicinal leech p. Dnieper River in the area of. Khortytsya found increasing its number by 2009 and a sharp decline in the number of 7-8 in 2010 as a result of the deterioration of the aquatic environment. Implementation: the pedagogical process (lecture courses and laboratory training in the basic disciplines and subjects of specialization) are coursework, undergraduate, diploma and master's works in the experimental work. For materials research during the reporting period (2009-2010) has been published in professional journals stattey 6, 14 abstracts, made 8 presentations at conferences, including 3 international, written 8 course, 17 undergraduate, 14 master's degree and 2 work. Farming written 3 contracts for a total of 5000 grn of optimization hirudotherapy. Scientists working a PhD and a doctoral dissertation. Scientific novelty: first observed strict cytophilous Aeromonas hydrophila in the intestinal epithelium of the medicinal leech, first established immunotropic effect hirudotherapy, bacteriostatic effect of exogenous biologically active substances of the medicinal leech; first identified characteristics of activated T-helper cells among circulating lymphocytes in the blood. Product Description popup.authors Копійка В.В. Федотов О.К. Фролов О.К. Фролова Л.О. popup.nrat_date 2020-04-02 Close