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Information × Registration Number 0211U000990, 0110U002278 , R & D reports Title To work out and perfect methodologies of the combined treatment of children with the prognostically unfavorable forms of neuroblastoma, Ewing sarcoma and sarcomas of soft tissue (non rhabdomyosarcoma) popup.stage_title Head Klymniyk Grygoriy Ivanovich, Registration Date 15-03-2011 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 Designed scheme of chemotherapy including topotecan combined with doxorubicin and vincristine showed sufficient direct efficacy in treatment children with poor prognosis forms of neuroblastoma. Complete remission and stabilization of process were reached in 84,2% patients of main investigation group, which are the same with results in treatment of this pathology in progressive countries, and better than results of treatment in control group (57%). Overall 3-year survival rate in patients of main group is 38%, in control group - 33,3%. The protocol, proposed for treatment of poor prognosis forms of Ewing sarcoma, demonstrated good direct treatment result (complete or very good partial response) in 9 of 15 patients (60%). The main early response evaluation criteria and factor of development of resistance or relapse is histological response. Proposed scheme of supportive low-dose metronome chemotherapy vinorelbine/cyclophosphamide is effective in 40% cases of poor prognosis forms of soft tissue sarcoma (non rhabdomyosarcoma) and could be recommended in treating patients with this pathology. Changes of cellular, humoral immunity and T-lymphocytes genome are observed initially in patients and in children with relapse. Product Description popup.authors Зарецький Михайло Володимирович Лузан Тетяна Олександрівна Льон Ганна Дарієвна Мельник Віктор Олександрович Павлик Сергій Володимирович Рушковський Станіслав Річардович Шайда Елен Вікторівна Шуміліна Катерина Станіславівна popup.nrat_date 2020-04-02 Close