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Information × Registration Number 0211U001008, 0107U003073 , R & D reports Title Desing of new technologies to diagnose development and progressing of an arterial hypertension popup.stage_title Head Dzyak G., Registration Date 05-01-2011 Organization Dniepropetrovsk State Medical Akademy popup.description2 In the paper are defined the innovative approaches to diagnosis and treatment of hypertension through improvement of existing methods of interpreting the results of ambulatory BP monitoring and establish clinical and genetic determinants of myocardial hypertrophy and left ventricular remodeling. It was demonstrated the feasibility of expansion of informing and diagnostic significance of the ambulatory BP monitoring in cardiology practice. The new technology of the AH degree staging was made on the results of ambulatory BP monitoring, which eliminates errors commonly accepted approach for verifying the degree of hypertension. It was revealed heterogeneity of the patients with essential hypertension at stage II by increasing the degree of BP variability. The role of the threshold level of blood pressure variability in different periods of the day, as a factor affecting the progression of BP rising in arterial hypertension was shown. It was developed a new method of BP variability analyzing based on dynamic characteristics, which allows to analyze the BP variability at a higher level, regardless of increasing pressure, nature of the BP circadian rhythm and to select patients with adverse course of AH. It was founded large differences in the impact of hemodynamic load associated with the rise of left ventricular hypertrophy progression according to the ACE gene polymorphism - no dependencies with genotype II and maximizing impact of high blood pressure and its chronobiologic characteristics at DD genotype. In patients with arterial hypertension shows the necessity to define the genotype of the renin-angiotensin system for the selection patients with high cardiovascular risk (genotype DD genotype of ACE gene and AT1 receptor gene CC to angiotensin II). These patients are needed to use more aggressive antihypertensive therapy and implementation of targeted measures to prevent complications of hypertension. Product Description popup.authors Алексєєнко Зоя Константинівна Колесник Тетяна Володимірівна Останіна Тетяна Георгіївна popup.nrat_date 2020-04-02 Close