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Information × Registration Number 0211U001120, 0107U012238 , R & D reports Title To determine the role of sphingomyelinase in apoptosis ceramide pathway at chemoradiation therapy for non-small-cell lung cancer for prognosis of its efficacy. popup.stage_title Head Mitryaeva N.A., Starenkiy V.P., Registration Date 19-01-2011 Organization Grigor'ev Institut for Medical Radiology popup.description2 Object of the research: Efficacy of chemoradiation therapy with etoposide in accelerated fractionation mode in 76 patients, activity of acid phingomyelinase, ceramides amount in the blood serum, sphingolipid amount in the tumor of the patients with non-small cell lung cancer. Objective: To investigate sensitivity of blood serum sphingomyelinase in patients with non-small cell lung cancer before chemoradiation therapy and its role in production of apoptosis inductor, ceramide, with the purpose to improve the control and prognosis of the treatment efficacy. Methods: Biochemical, electron microscopy, morphology, clinical instrumental, radionuclide, statistical. Results and their novelty: Efficacy of chemoradiation therapy with etoposide in accelerated fractionation mode when compared with both traditional and accelerated irradiation without etoposide in non-small-cell lung cancer was demonstrated. It was proven that activity of acid secreted sphingomyelinase increased 2.6 times, ceramide amount in 86.2% of patients after chemoradiation therapy with etoposide against a background of the tumor regression over 50%. For the first time, the possibility of application of active acid sphingomyelinase during chemoradiation therapy with etoposide was considered. The criteria of application of the ratio of activity of acid sphingomyelinase before to after treatment were worked out. The experiments allowed establishing that combined action of ionizing radiation and etoposide promoted increase of sphingomyelinase activity in the blood serum against a background of apoptosis process activation in the tumor. Efficacy of introduction: 5 articles, 6 abstracts were published. 2 patients for a useful model were obtained. Sphere of application: Radiation medicine, oncology. Product Description popup.authors Білий О.М. Бабенко Н. Бакай Т.С. Гребіник Л.В. Гусакова В.В. Лукашова О.П. Мітряєва Н.А. Сегеда Т.В. Спузяк Р.М. Старіков В.І. Старенький В.П. Тарасова О.М. Тихомирова М.. Узлєнкова Т.Є. Якімова Т.П. popup.nrat_date 2020-04-02 Close