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Information × Registration Number 0211U001144, 0109U001567 , R & D reports Title Working out of methodology of diagnostics immune disease conditions and the substantiation of system of stage-by-stage rehabilitation of children - inhabitants is radioactive the polluted territories which were born from persons, irradiated in children's age popup.stage_title Head Bazyka Dimitriy Anatoliovich; Stepanova Evgeniya Ivanovna., Registration Date 20-01-2011 Organization Research Centre for Radiation Medicine popup.description2 Object of study - health, indicators of cellular, humoral immunity and functional activity of neutrophils, the level of free radical processes in biological matrix of the children under conditions of adverse exogenous and endogenous factors. Objective - based on the most informative definition of complex clinical and immunological parameters to optimize the method of diagnosis of immunodeficient states in children - residents of contaminated territories, born from those exposed to radiation in childhood and to develop an algorithm for its application. Methods: Clinical, immunologic, laboratory and statistical. Results and novelty: the most significant changes in immunological parameters have children who live in the most contaminated areas. They observed reduction of T - lymphocytes unbalance their regulatory subpopulations, reducing the percentage of B - lymphocytes, decreased concentration of serum immunoglobulin A and immunoglobulin G; suppression of phagocytic function of neutrophils, increase in the intensity of free radical processes in serum and erythrocytes. The complex clinical and immunological parameters and the method of diagnosis of immunodeficient states in children - residents of contaminated territories, born to those exposed to radiation in childhood, which in relative simplicity, low cost and using only non-invasive methods allows to get explicit and objective quantitative criteria. With it you can establish the presence of secondary immune deficiency, ranging from primary health care. Product Description popup.authors Ільєнко Ірина Михайлівна Бєляєв Олег Володимирович Бєляєва Надія Володимирівна Вдовенко Віталій Юрійович Колпаков Ігор Евгенович Кондрашова Валентина Григорівна Литвинець Оксана Михайльівна popup.nrat_date 2020-04-02 Close