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Information × Registration Number 0211U001145, 0109U001568 , R & D reports Title Estimation of chronic lymphocytic leukemia risks among the contingents suffered due to Chornobyl catastrophe on the basis of investigation of gene coding the protein of reparation polymorphism popup.stage_title Head Chumak Anatoliy Andreevich, Доктор медичних наук Registration Date 20-01-2011 Organization Research Centre for Radiation Medicine popup.description2 The aim of the work is to study the frequency of polymorphisms of separate DNA repair genes in persons without oncohematological diseases. The object of study: 196 persons without oncohematological diseases, among them 87 persons exposed to the ionizing radiation (the main group) and 109 persons of the control group. The study of polymorphisms of DNA repair genes (XRCC1, XPD, XRCC3) was performed using polymerase chain reaction and restriction of its products. The main results: the frequencies of polymorphisms of DNA repair genes XRCC1-199, XPD-751, and XRCC3-241 among persons without oncohematological diseases were not significantly different from literature data. Differences depend on radiation anamnesis of observed persons were not found except the tendency to decreasing of number of XRCC1 Gln399Gln homozygotes among convalescents of acute radiation syndrome. There were some differences in frequency of somatic diseases in persons of the main group: higher frequency of chronic hepatitis and chronic gastritis in XRCC1 Gln399Gln homozygotes; lower frequency of chronic hepatitis, chronic obstructive lung disease and chronic bronchitis inXPD Gln751Gln homozygotes. Product Description popup.authors Абраменко Ірина Вікторівна Білоус Надія Іванівна popup.nrat_date 2020-04-02 Close