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Information × Registration Number 0211U001199, 0109U007047 , R & D reports Title Physico-chemical and biological mechanisms of cell alterations under photodynamic therapy of tumors assisted by porphyrin conjugates with gold nanoperticles and semiconductor nanocrystals/ popup.stage_title Head Gamaleia Nikolai Fedorovich, Registration Date 24-01-2011 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Nanocomposites of hematoporphyrin and chlorin e6 (well-known photosensitizers for the photodynamic therapy of tumors) with colloidal gold were sinthesized, and their spectral characteristics were investigated. The nanocomposites obtained were shown to efficiently induce the formation of singlet oxygen and free radicals under light irradiation both in model solutions and malignant cells suspensions. In in vitro experiments with human leukemic cells it was established that photodynamic activity of the nanocomposite hematoporphyrin -colloidal gold is 17-20 times higher than for free hematoporphyrin. The better activity of composite porphyrins was also demonstrated in studies on photodynamic therapy of experimental tumors, transplanted in mice - metastasizing Lewis lung carcinoma and non-metastasizing sarcoma 180. The treatment efficiency could be further enhanced by utilization of a fractionated regimen of tumor irradiation instead of continuous. Product Description popup.authors Гамалія Микола Федорович Дегода Володимир Якович Лісняк Іван Олексійович Лосицький Михайло Юрійович Мамчур Анатолій Анатолійович Прокопенко Ігор Вікторович Усатенко Олександр Васильович Шишко Євгенія Денисівна Щербаков Олександр Борисович Ящук Валерій Миколайович popup.nrat_date 2020-04-02 Close