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Information × Registration Number 0211U001989, 0108U001791 , R & D reports Title Age-related morpho-functional peculiarities of Blood-Tissue Barriers under experimental diabetes according to the data of electron microscopy, ultracytochemistry and immunohistochemistry popup.stage_title Head Kvitnitzkaya-Ryzhova Tatiana Yurievna, Registration Date 24-02-2011 Organization State Institution "Institute of Gerontology AMS Ukraine" popup.description2 Pathogenetic essence of diabetic angiopathy is characterized by a violation of intercellular and cell-matrix interactions in histo-hematic barriers, decreased intensity of cytochemical reaction of alkaline phosphatase (marker enzyme of microvasculature) and by endothelial dysfunction associated with the destruction of endothelial cells (EC), leading to apoptosis (rarely - necrotic) death. In diabetes mellitus an increase in apoptotic cell death in all studied organs (pancreas, kidney, liver, heart, brain, aorta) is noted, whereby in EC are affected to a greater extent affected EC. The process of apoptosis is characterized by a pronounced age dependence - apoptotic index significantly increased with age. Thus, EC apoptosis plays a key role in the development of diabetic micro- and macroangiopathy, which is significantly increased with aging. Product Description popup.authors Балла Ірина Анатоліївна Квітницька-Рижова Тетяна Юріївна Малишева Світлана Петрівна Михальський Сергій Анатолійович Ступіна Олександра Семенівна Хаблак Галина Віталіївна popup.nrat_date 2020-04-02 Close