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Information × Registration Number 0211U002876, 0108U000192 , R & D reports Title To develop complex methods of treatment of patients with gastric and colorectal cancer by means using new and improvements technology of surgical, chemo-radiotherapy and biotherapy popup.stage_title Head Shchepotin Igor Borysovych, Registration Date 09-03-2011 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 The analysis of results of applying the method of intraoperative diagnosis of the degree of spread of cancer through research RSH guard nodes. The method enables high accuracy to detect signal components and examining them with immediate histological examination, to determine the volume limfodysektsiyi and improve radykalyzmu surgery. Studied in a randomized trial immediate results of treatment of patients with RSH in the performance limfodysektsiy in the volume of D1 and D2 and bursektomiyi. The technique does not increase the number of postoperative complications. Established high sensitivity and specificity of the markers p53, bcl-2, VGEF and 8-oxodGu in patients with RS. Markers can be used for individualized treatment of patients with common forms of RS. Determination of sensitivity to CT groups can individualize treatment for patients with common forms of RS, to increase the number of partial regression in 2,5-3 times lower total jewel treatment. Application of SAW adjuvant in combined treatment of patients with resectable RS, improves the 2-year survival rates compared with clean surgical treatment by 13%. The course of vaccination induces development of delayed skin reaction that is a sign of activation of the immune system and the effectiveness of therapy. Studied the results of combined treatment using MKRR radical operation and adjuvant CT. To increase the effectiveness of treatment of this category of patients may by isolating groups of patients with unfavorable factors and individualized modes ryzmku CT. Using molecular tests and determination of tumor proliferative capacity allowed these patients to individualize adjuvant CT regimes, to increase the length of time without relapses over a year. The efficacy of adjuvant treatment in intensive regimes FOLFIRI / FOLFOX: 2-year survival was 94%. As a result of a randomized study proved that combined treatment of patients with resectable CRC with neoadjuvant radiotherapy (small fraction) is an effective method that allows you to increase 2,5 times the number of SZO and improve quality of life of patients. In 38% of patients with an objective effect of treatment has come in the form of partial or complete tumor regression (due to decrease in the T). Randomized study found that use of multimodal FTS program increases the effectiveness of surgical treatment of rock and RSH. By using epidural anesthesia, minimizing surgical intervention, early mobilization and nutrition programs FTS helps reduce the pain syndrome is 3 times and rapid recovery of gastrointestinal tract (2 day). Established that the use of FTS programs and more effective rehabilitation of patients with stage IV Rock, it was possible to start in the early period of palliative CT in the required amount. Using FTS enables double lower treatment costs, resulting in budgetary savings. Results of research in applied Chernihovskomu, Poltava, Chernovtsy regional oncology clinics. Product Description popup.authors Васильєв Олег Валентинович Жуков Юрій Олександрович Колеснік Олена Олександрівна Лукашенко Андрій Володимирович Розумій Дмитро Олександрович popup.nrat_date 2020-04-02 Close