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Information × Registration Number 0211U004185, 0108U001148 , R & D reports Title Pecularity of the glucose homeostasis disturbance during ontogenetic stages depending on gestational age and pubertal development (clinical investigation) popup.stage_title Head Khyzhnyak Oksana Olegovna, Registration Date 28-01-2011 Organization Ukrainian Research Institute of Endocrine Diseases Pharmacotherapy popup.description2 The purpose of the investigation is to establish the role of gestational age at birth and the flow of puberty in the formation of fasting hyperglycemia, glucose intolerance and the development of diabetes in people of all ages; to improve the diagnostic scheme of violations and rationale of the modern strategy of preventive / rehabilitative therapy. The significantly higher incidence of overweight children with general change in body weight at birth among the children with endocrinopathy compared with general population rates was revealed. The risk factor of increased body weight at birth may be considered a significant number of patients with type 2 diabetes among relatives of the first and second degree relatives. The degree of insulin resistance in obese adolescents according to sex and birth weight was determined. Developed mathematical algorithm allows on the first stage of the survey with a probability of 86% to diagnose "metabolic syndrome" in male adolescents with obesity. Diagnostic criteria of metabolic syndrome in male adolescents with obesity should be considered the level of the index of HOMA-IR higher than 3.9, and basal leptin levels in the blood higher than 37.7 ng / ml. An additional risk factor for the formation of the lipid metabolism disorders in adult patients with obesity and / or with type 2 diabetes may be birth weight. Therapy schemes taking into account a combination of options dysfunction beta-cells and insulin sensitivity were improved. Product Description popup.authors Алесеєва Ірина Ігорівна Атраментова Любов Олексіївна Барабаш Надія Євгеніївна Гладких Олександр Іванович Гогітідзе Теона Гурамівна Горшунська Мар’яна Юріївна Грязнова Галина Федорівна Завадська Наталія Володимирівна Левченко Тамара Петрівна Лутай Тетяна Володимірівна Манська Катерина Геннадіївна Микитюк Мирослава Ростиславівна Полторак Вікторія Віталіївна Суліма Тетяна Нінелівна Тамбовцева Тіна Костянтинівна Тихонова Тетяна Михайлівна Хижняк Оксана Олегівна Червенко Олена Леонідівна Черевко Ірина Григоріївна Штандель Світлана Анатоліївна popup.nrat_date 2020-04-02 Close