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Information × Registration Number 0211U004193, 0111U002396 , R & D reports Title nvestigation of new 1,4- benzodiazepine-2-one esters hydrolysis using free and immobilized enzymatic systems of animals popup.stage_title Head Romanovskaya І.І., Доктор біологічних наук Registration Date 26-01-2012 Organization A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 The object of research - pig liver carboxylesterase, of 3-hydroxy-1,4-benzdiazepin-2-one esters. Objective: to study the features of enantioselective enzymatic hydrolysis of 1,4-benzdiazepin-2-one new esters. The influence of 17 metal ions on enzyme activity, was studied an activating effect of Na + ion in esterase activity with an increase of 16% of this was shown. Obtained QSAR-model, which satisfactorily describes the change in carboxylesterase esterolytic activity in the presence of metal ions. The dependence of ester bond enzymatic hydrolysis degree of new 1,4-benzdiazepin-2-one derivatives from their structure was established Product Description popup.authors Декіна Світлана Сергіївна Осетров Валерій Євгенович Романовська Ірина Ігорівна Севастьянов Олег Всеволодович Шестеренко Євгенія Аркадіївна Шестеренко Юлія Аркадіївна popup.nrat_date 2020-04-02 Close