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Information × Registration Number 0211U004420, 0109U007049 , R & D reports Title Stady of the cancer vaccine, prepared on the base of oncofetal antigens and proteincontaining metabolites of B. subtilis. popup.stage_title Head Karaman Olga Mychaylivna, Registration Date 04-02-2011 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Introduction of mice С57BL with Lewis lung carcinoma embryonic chicken proteins leads to the formation of these animals in a metastatic tumor and protection. It is shown that the immune response to xenogeneic fetal antigens may be enhanced by proteincontaining metabolite of B. subtilis B-7025 with molecular mass 70 kDa as adjuvants. Found that the vaccine is designed based on embryonic chicken proteins 7 days of gestation and proteincontaining metabolite of B. subtilis B-7025 with molecular mass 70 kDa, has some antitumor activity against Lewis lung carcinoma and results in inhibition of metastasis (50-60%). The most significant antitumor effect observed with combined application of surgical removal of tumor and enter the corresponding xenogeneic vaccine. Investigation of the effectiveness of anticancer vaccines based on xenogeneic embryonic proteins showed that one of the main mechanisms of its action is the induction of antitumor activity of macrophages (increase their cytotoxic activity by an average of 30-50%) and preservation of antitumor immune response in a more remote period of tumor growth. It is proved that protein xenogeneic fetal tissues, particularly chicken embryo proteins, can influence the tumor, which opens prospects for their use as "universal" specific antigenic complexes for an effective antitumor vaccine. Product Description popup.authors Караман Ольга Михайлівна Симчич Тетяна Василівна Шпак Євген Григорович popup.nrat_date 2020-04-02 Close