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Information × Registration Number 0211U004513, 0110U006130 , R & D reports Title Nanoconjugates of novel antitumor drugs compounds based on the sopecific ligands of quadruplex DNA - telomerase inhibitors. Stage 1. Preparation of the potential ligands of quadruplex DNA based on the derivatives of porphyrins, cyanines and berberine popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 04-02-2011 Organization Institute of molecular biology & genetics popup.description2 The design of structures was performed, methods of synthewsis werer developed and a series of the derivatives f tetra(methylpyridinium)porphyrin, its complexes with Zn(II) and Mn(III), unsymmetric 2-alkylamino-substituted monomethinecyanines and berberine were obtained. Methods for the introduction of reactive groups into molecules were elaborated for their attachment to polymers. The interaction of ligands with G-quartets was studied by computer modeling methods. Work on the functionalization of polyethylene glycol and dextran was performed. Practical introduction of TRAP method to study the effect of compounds on telomerase activity was started. Product Description popup.authors Авдєєв Станіслав Сергійович Арешков Павло Олександрович Дубей Лариса Василівна Криворотенко Дмитро Владиславович Кузів Ярослав Богданович Негруцька Валентина Володимирівна Платонов Максим Олегович popup.nrat_date 2020-04-02 Close