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Information × Registration Number 0211U004601, 0109U001565 , R & D reports Title To examine the state of protein and mineral methabolism of bone tissue for children with oncologic and haematological pathology, which were under influence of ionizing irradiation as a result of Chernobyl accident, for the improvement of treatment and prophylactic measures popup.stage_title Head Bruslova Ekaterina Mihailovna, Registration Date 10-02-2011 Organization Research Centre for Radiation Medicine popup.description2 The object of research: 712 children with acute leukemia and persons of comparison group. Target of work: to research the state of protein and mineral metabolism of bone tissue in children with oncohematologic pathology, who exposed ionizing radiation as a result of Chernobyl accident. Methods of research: clinical, immunological, biochemical, mathematical. The changes were detected in the state of protein and mineral metabolism of bone tissue in children with acute leukemia. During initial period of disease the excretion of oxyproline with urine was heightened, the level of glycine, praline, asparaginic acid was lowered; this indicates the destruction of collagen. It was established, that changes in the excretion of calcium phosphate, amino acids misbalance in urine is followed by manifestations of osteoporosis. Sick children had lower content of free oxyproline in urinal peptides in comparison with healthy children. Product Description popup.authors Ільєнко І.М. Базика Д.А. Володіна Т.Т. Дмітрієва К.Д. Кузнєцова О.Є. Кучер О.В. Ляшенко Л.О. Пушкарьова Т.І. popup.nrat_date 2020-04-02 Close