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Information × Registration Number 0211U004603, 0110U000180 , R & D reports Title A study of the modifying role of the ionizing radiation on the gene regulation of telomere length and apoptosis in cerebrovascular pathology of the late period after exposure popup.stage_title Head Bazyka Dimitry, Loganovskiy Konstantin, Registration Date 10-02-2011 Organization Research Centre for Radiation Medicine popup.description2 Report of the research work: 79 p., 23 tables., 21 fig., 1 formula, 71 source of literature. Research object: lymphocytes of peripheral blood is 50 radiation-exposed persons and persons of control group. Aim of the study - to define the peculiarities of the expression of genes-regulators of apoptosis and telomere complex and estimate changes the programmed cell death and telomere length in peripheral blood lymphocytes of Chornobyl clean-up workers. Research methods - clinical, immunological, cellular-molecular, statistical, analytical. Results: Changes of cellular immunity and decrease of number of natural killer cells (<250 mSv) can testify the defect of immune supervision. The increase of CD95+ cell fraction is shown and a positive correlation with irradiation dose. In the group of radiation-exposed to low doses a tendency is demonstrated of a decrease of cell numbers at the early stages of apoptosis. A decrease of the relative telomere length iwas shown in both groups of the radiation-exposed and non-irradiated patients with cognitive disorders with no clear dependencies with dose of exposure and age. Changes in gene expression (RQ) included a decline in expression of genes regulating apoptosis: TR53, TR53I3 and FASLG as well as genes - regulators of telomere length - Terf1 and Terf2., and hyperexpression of antiapoptotic genes BAX and CCND1, that are reported to be associated with cellular transformation. For some genes a dependency was shown for RQ and the dose of exposure. Cerebrovascular pathology with a predomination of personality organic disorders and affective deppresive and anxiety changes were more prominent in a group of Chornobyl clean-up workers. Results of the stage of research were reported in 9 publications , 2 presentations at the international conferences. Product Description popup.authors Ільєнко Ірина Миколаївна Антипчук Катерина Юріївна Бєляєв Олег Анатолійович Бєляєва Надія Володимирівна Бомко Марія Олександрівна Гресько Марина Володимирівна Колосинська Олена Олександрівна Крейніс Георгій Юрійович Логановська Тетяна Костянтинівна Лясківська Олена Вікторівна Мазніченко Оксана Леонідівна Чумак Станіслав Анатолійович Чупровська Наталія Юріївна popup.nrat_date 2020-04-02 Close