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Information × Registration Number 0211U004604, 0110U000181 , R & D reports Title Analysis of neurobiological mechanisms in forming of long-term neuropsychiatric effects after the evolutionary brain's irradiation popup.stage_title Head Loganovsky Kostyantyn Mykolayovych, Bazyka Dimitry, Registration Date 10-02-2011 Organization Research Centre for Radiation Medicine popup.description2 Object of study: It is inspected 80 in utero of the radiation-exposed persons and 40 non-irradiated persons in 1986-1987 birth. The purpose of the study - to study neurobiological mehanizms of formation at a young age neuropsychiatric effects of exposure in the prenatal period and at the age of 0-1 years due to the Chernobyl disaster. Purpose of phase 2010: to give prospective neuropsychiatric characteristics of prenatally exposed individuals and identify specific immunobiological and molecular-biological changes in intrauterine brain damage. Methods - Clinical, neuropsychological, neurophysiological, іmunologicheskie, statistics. A local database of persons irradiated in utero as a result of the Chernobyl disaster. An assessment of mental health and nervous system of these individuals on the basis of prospective observation from 1992 The tendency to realize the potential neuropsychiatric effects in the form of paroxysmal states (including epilepsy), organic mental disorders, demyelinating diseases and disorders of the spectrum of schizophrenia. Violation of the dominant (left) hemisphere was manifested in the form of specific neurocognitive deficits: impairment of verbal intelligence, levovisochnoy epilepsy, left-sided fronto-temporal cerebral lesions. The presence of atypical-induced posttraumatic stress disorder (PTSD), associated with the Chernobyl disaster, the increase in severity of depressive symptoms. In individuals with srednegruppovym value integral fetal dose 66,26 ± 36,67 mSv identified cellular manifestations of destabilization of the immune homeostasis. The direction of deviation of proapoptotic parameters may indicate a decrease in apoptotic potential of lymphocytes or blocking the entry of spontaneous lymphocyte apoptosis. 3 scientific publications are published, 2 reports at conferences and seminars. Product Description popup.authors Ільєнко І.М. Андоній Г.В. Антипчук К.Ю. Бєляєв О.А. Бєляєва Н.В. Бомко М.О. Голярник Н.А. Гресько М.В. Зданевич Н.А. Колосинська О.О. Крейніс Г.Ю. Логановська Т.К. Лясківська О.В. Мазніченко О.Л. Чумак С.А. Чупровська Н.Ю. popup.nrat_date 2020-04-02 Close