Search academic texts

Information × Registration Number 0211U004788, 0109U005633 , R & D reports Title Mechanisms of the control of cancer cell migration, invasion and survival by urokinase and urokinase receptor popup.stage_title Head Drobot Lyudmyla Borysivna, Registration Date 28-02-2011 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 One of the key receptor systems involved in the control of cell adhesion, migration and invasion is urokinase-type plasminogen activator (urokinase), its receptor and inhibitor (uPА/uPAR/PAI-1). The aim of the study was to investigate the mechanisms of uPAR signaling through transactivation of epidermal growth factor receptor (EGFR) in human breast adenocarcinoma cell line MCF-7 as well as the regulatory role of adaptor protein Ruk/CIN85 in these processes. The obtained results indicate the involvement of adaptor protein Ruk/CIN85 in the functioning of plasminogen activation system in human breast adenocarcinoma cells through the activation of signaling pathways, increase of PAI-1 expression level as well as activity of HIF-1alfa та NF-kappaB transcription factors. Product Description popup.authors Биць Надія Вікторівна - к.б.н. Козлова Ніна Володимирівн Марченко Світлана Миколаївна Самойленко Анатолій Анатолійович popup.nrat_date 2020-04-02 Close