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Information × Registration Number 0211U004791, 0109U005634 , R & D reports Title Characterization of molecular mechanisms of action of B1 vitamin and its derivatives on metabolism and signaling in neural tissue popup.stage_title Head Parkhomenko Yuliya Mikhailovna, Registration Date 28-02-2011 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The aim of this project - the study and characterization of molecular mechanisms of action of vitamin B1 (thiamine) and its biologically active derivatives in the nervous tissue. The assumption about the existence in nerve cells of a coordinated regulation of thiamine and / or its derivatives a series of metabolic and transport processes, that are essential for the synthesis of neurotransmitters and holding a signal in the CNS, had been confirmed. The data confirm the assumption that various sites on thiamine binding protein (ThBP) responsible for the two activitiest. It is shown that the membrane thiamine triphosphatase (ThTPase) is part of the ThBP, and ThBP subunit with a molecular mass of 35 kDa is homologous to the cytosolic ThTPase. The experimental confirmation of the independence of the activity of ThDP-dependent enzymes from content of ThDP in chronic alcoholism had been received Product Description popup.authors Протасова Зоя Степанівна Сергійчук Андрій Анатолієвич Степаненко Світлана.Петрівна Строкіна Анастасія Олександрівна Чеховська Лілія Іванівна popup.nrat_date 2020-04-02 Close