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Information × Registration Number 0211U004844, 0108U001473 , R & D reports Title Substatiation of modern principles organism detoxication during saturnism on the base of complex using of remedies with sorptive, chelating, membrane-stabilizing and antioxidation properties popup.stage_title Head Stezhka Vasiliy Ananievich, Registration Date 24-02-2011 Organization State Institution "Institute for Occupational Health of the Academy of Medical Scieces of Ukraine" popup.description2 Complex medicaments (fine dispersed dust of calcium alginate (0,2 g/rat); tabletized quercetine produced by Borschagivsky chemico-pharmacological plant (1 mg/rat); vitamine D cristalline, chemically pure (40 IU/rat); calcium gluconate (10 mg/rat) was used for prophylaxy of lead intoxication development. This combination decreased morphological sings of toxic injures of liver, kidneys, adrenal glands and immune system organs (thimus, spleen, mesenteric lymphatic nodes); intensity of apoptosis in the nucleus of hepatocytes and spleenocytes normalized. Also are normalized: oxide-antioxide balance in blood plasma and peroxide oxidation process of lipid and liver protein syntetic function, damage in eritrocitar, leucocytic and thrombocytic blood systems and in cellular structure of leucogram, activity of intracellular ensymes in the leucocytes; decreasing of lead concentration in the blood, liver, kidneys, spleen, brain, bone tissue during exposition period. Prolonged protecte effect of complex medicaments in relation to leasions of homeostasis in rats as consequence of endogenic lead and prolonged detoxic effect in relation to toxicokinetic component lead intoxication and lead elimination stimulation through liver and kidneys without transfer of chelating lead to brain tissue during recovery periode after exposition. Using of complex medicaments for saturnism treatment in rats is safe and effective as its provide normalizing influence on free radical system of perozide oxidation of lipids and state of oxide-antioxide balance in blood plasma and clear antioxidizing protective effect against development characteristic for influence endogenic deposited lead structure-functional damage of liver tissue, significantly accelerate cleaning liver, spleen and kidney tissue from lead decrease its blood concentration, and not provocating unwanted side effects according with morphological studies of liver, kidneys, adrenal glands, immune system organs and phenomenon of lead transfer to brain tissue. Product Description popup.authors Діденко М.М. Зінченко В.М. Леоненко О.Б. Покровська Т.М. Синиченко С.В. Стежка В.А. popup.nrat_date 2020-04-02 Close