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Information × Registration Number 0211U005220, 0107U012349 , R & D reports Title To study ultrasound, cytological, radiological, hormonal and clinical indices in young patients with thyroid cancer in order to imporove the quality of preoperative diagnosis and efficacy of postoperative follow-up. popup.stage_title Head Markov Valentyn Vasylyovych, Registration Date 04-03-2011 Organization State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism оf the Academy of Medical Scienses of Ukraine" popup.description2 Object: diagnostic, clinical, and therapeutic factors that influence life expectation for young patients with thyroid cancer. Aim of the work: improving preoperative diagnosis and postoperative clinical follow-up in terms of prolongation of life expectation for young patients with thyroid cancer. Methods: ultrasound, cytological, radiological, instrumental methods. Theoretical and practical results: it has been studied the pooled diagnostic accuracy of combined ultrasound and cytological signs of thyroid neoplasms; immunocytochemical, cytomorphological, and cytochemical signs of radioresistant thyroid metastases; efficacy of radioiodine therapy for distant metastases in young patients with differentiated thyroid cancer; the efficacy of transcutaneous sclerozing ethanol therapy of benign cystic thyroid neoplasms; the status of cardiovascular and reproductive systems in young patients with thyroid cancer after surgery and radioiodine therapy. Novelty: for the first time, a combined comparative analysis has been conducted, of ultrasound features of papillary carcinomas in subjects who were children at the moment of the Chornobyl accident, with aspiration biopsy data. Disturbances have been revealed, of electric stability of myocardium in the presence of suppressive therapy with thyroxine, and a correcting cardiogenic therapy has been suggested. The results obtained suggest that the informativity of cytology conclusion “papillary thyroid carcinoma” has been confirmed with accuracy in all cases by a pathomorphology study. The presence of Nekhoroshkov’s complex was reported in bioptates of radioresistant metastases 3,6 times more often compared to general population of papillary carcinomas, and it may represent a cytological prognostic factor for appearance of radioresistant metastases. Radiotherapy is a leading and highly effective method of treatment of distant metastases of differentiated thyroid cancer. In young patients with thyroid cancer in pre- and postoperative periods, in the presence of suppressive therapy, abnormalities in cardiac rhythm in terms of more frequent episodes of tachyarrhythmia and extrasystole were noted, which suggests a disturbance of electric stability of myocardium. Disturbances of endocrine homeostasis in women after thyroidectomy and raioiodine therapy for a differentiated thyroid cancer were associated with development of anovulatory menstrual cycles, disturbance of follicle maturation at different stages of their development, development of lutein phase insufficiency. Efficacy of introducing: the data obtained will be used to improve preoperative diagnosis of thyroid tumours and radioiodine treatment of metastases. Advantage over analogues: a scale has been suggested for measurement of thyroid volume errors and pharmacotherapy of disturbances of cardiac rhythm and tachycardia in the presence of suppressive therapy with thyroxine. Field of application: endocrinology, oncology, radiology. Product Description popup.authors Божок Ю.М. Булат О.В. Гулєватий С.В. Зелінська Г. В. Зубкова С.Т. Кучменко Т.М. Марков В.В. Матящук С.І. Моторний Є.О. Найда Ю.М. Шелковий Є.А. popup.nrat_date 2020-04-02 Close