Total number
Full text
Total number
Full text
Number of local repositories
Full text
0211U005303,
0107U010019
,
Scientific ground of short-term tests for hygienical estimation of carcinogenic factors' danger
Chernichenko Igor,
11-04-2011
Ukrainian scientific centre of hygiene
An object of researches is not thoroughbred white mise, benzo(а)pyrene (BP), phenol, indexes of genotoxic effect, morphological and immunological changes. A purpose is a scientific ground of criterion meaningfulness of speed-up tests at the estimation of carcinogens factors. Research methods - experimentally oncologic, pathomorphological , immunological, cytogenetic (micronuclear-test), mathematical. As a result of the conducted complex researches of immunological and genotoxic effects, immunological status and morphological changes it is set in chronic experience : dependence of development of tumours, genotoxic effect from a dose and ways of receipt of BP separately and in combination with a phenol; oppressing of cellular link of immunity in an early period; correlation between the indexes of genotoxic effect and immunosuppression after influence of BP in a dose which induces tumours. The set conformities to law of changes a genotoxicity and immunosuppression allow to examine them as possible short-term tests and criteria for the estimation of carcinogenic danger of compounds.
Баленко Н.В
Зінченко Н.О.
Литвиченко О.М.
Осташ О.М.Швагер О.В
Першегуба Я.В.
Смірнова Г.І.
Соверткова Л.С.
Швагер О.В.
2020-04-02
Updated: 2025-12-07
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