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Information × Registration Number 0211U005543, 0110U005086 , R & D reports Title Stuty of the role of TGFb-1 in doxorubicin-induced inhibition of methastasis formation in order to develop new efficient drugs for tumor therapy popup.stage_title Head Filyak Yevhen Zenoviyovyc, Registration Date 10-06-2011 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 It was received results of exposure of doxorubicin to promoter TFRbeta -dependent and TFRbeta-independent genes, namely reporter promoter system of TFRbeta-1-dependent promoter CAGA, SBE / FBE, SRE, FAS, p300, PAI-1, and independent TFRbeta-1 promoter: c -myc. It was shown that doxorubicin significantly inhibits activity of TFRbeta-1 dependent promoter activity and does not inhibits TFRbeta-1 independent promoters. It was found that doxorubicin inhibits the activity of components TFRbeta-1 signaling pathway, and in particular reduces the expression of proteins Smad2, Smad3 protein and increases expression of inhibitory Smad7, reduces the level of protein phosphorylation of Smad2 and Smad3. Thus, doxorubicin did not influences significantly the level of protein expression and phosphorylation of Erk1 and Erk2 - components of TFRbeta-1-independent c-myc signaling pathway. Product Description popup.authors Білий Ростислав Олександрович popup.nrat_date 2020-04-02 Close