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Information × Registration Number 0211U005566, 0106U004245 , R & D reports Title To develop develop methods and means facilities of minimization of recipient of mycotoxins in the organism of animals and easing of their toxic action. popup.stage_title Head Khmelnitskiy Grigory Aleksandrovich, Registration Date 05-07-2011 Organization National agricultural university of Ukraine popup.description2 Research subject: rats and piglets T-2 toxicosis, rats chronic T-2 and zearalenone toxicosis, clinical state, pathogenesis, treatment. Investigation methods: clinical, biochemical, histochemical, mycotoxicological, chromatographical, statistical. Goal of the research is to study of nuclivet and unitiol efficiency at animal T-2 toxicosis; sorbents and biologically active additives clinical efficiency at rats chronic T-2 and zearalenone toxicosis; determination of the adsorbents sorption properties to T-2 and desoxynivalenone using high-yield liquid chromatography; to develop the prediction methods of enterocorbents clinical efficiency in animals mycotoxicoses by in vitro bioassay with plant test- objects involvement. In the experiment, it was established that nuclivet and unitiol stimulate the enzyme systems' activity of T-2 toxin biotransformation, and inhibit its toxic influence. The bioantioxidants (?-tocopherol acetate, retinol palmitate, cholecalciferol, and ascorbinic acid) adding to the main diet of rats with T-2 toxicosis helps to inhibit lipid peroxidation, improve their performance status, and feeds assimilability. In the experiment with piglets affected by T-2 toxin, it was proved that nuclivet improves the mineral metabolism parameters, transaminases activities, increases the platelets general amount, and helps to increase the body gains as much as 1,8-2. Aquaton has an apparent fungistatic activity to toxigenic micromycetes. Administration of mineral sorbents and biologically active additives are proved to be one of the most advanced methods of T-2 toxin action neutralization. The techniques of mycotoxins detection by high-yield liquid chromatography and enterosorbents clinical efficiency by in vitro bioassay with plant test objects involvement in animals toxicoses have been developed. Industry of application is veterinary medicine. Product Description popup.authors Іщенко Вадим Дмитрович Бойко Григорій Васильович Духницький Володимир Богданович Корзуненко Володимир Дмитрович Панько Микола Федорович Хмельницький Григорій Олександрович Хмельницький Леонід Григорович popup.nrat_date 2020-04-02 Close