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Information × Registration Number 0211U005787, 0109U004110 , R & D reports Title Development of innovative molecular genetic methods of diagnostics and choice of tactic of individual therapy of patients with mioma and breast neoplastic processes. popup.stage_title Head Zaporozhan Valeriy, Registration Date 14-12-2011 Organization Odesa National Medical University popup.description2 Genes' expression analysis pointed to a group of genes, such as MSH3, BARD1, SIRT17, ECHDC1, CDH27, SPP1, DNMT3, EPOR, TFF1, and AKAP9 that could be used for prediction of preneoplastic processes malignization in mammary gland. There were also identified genes that could be used for prediction of adenocarcinoma's progression and antiestrogen therapy answer. It was first detected gene PYGO1 methylation in breast adenocarcinoma. Obtained data shows the involvement of DKK4, SFRP5, WIF1 and PYGO1genes in breast tumor process development that could also be a malignization marker. Genes (CLDN1, FGF7, HNRPM, ISOC1, MAGEC1, MAPK12, RFC, TIE1, TNFRSF21) that were identified during genes' expression analysis in leiomyoma suppose to be potential or predictable leiomyoma's markers and so they can be useful as a source of new therapeutic candidates. Product Description popup.authors Бубнов Владимир Вячеславович Вербицкая Томара Георгиевна Запорожан Валерий Николаевич Зеленіна Юлія Володимирівна Олейник Анна Николаевна Омельчук Олександра Євгеновна Павлова Валентина Іванівна Перепелица О.П. Поклад Ганна Миколаївна. Савченко Наталья Йосипівна popup.nrat_date 2020-04-02 Close