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Registration Number

0211U005870, 0110U005770 , R & D reports

Title

Development of biotherapy drugs (biomolecules) by RNA-based technologies to correct molecular disorders found in tumor cells

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Head

Chekhun Vasyl Fedorovych,

Registration Date

13-12-2011

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

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We studied activity and expression of iron metabolism regulator proteins in sensitive and resistant to antitumor drugs human breast cancer (BC) MCF-7 cells. We detected elevated expression of transferrin receptors, transferrin, ferroportin and hepcidin in both resistant cell lines. Development of drug resistance phenotype was accompanied by changes in expression of ferritin heavy chanins and relocalisation of its light chains from cytoplasm into the nuclei of resistant cell lines. Also we found that development of drug resistance phenotype as to cisplatin, as to doxorubicin included hypermethylation on transferrin receptor 1 gene promotor. These data suggest that changes in iron metabolism could be one of the major parts of development of resistance phenotype to antitumor drugs with different mechanism of action.

Product Description

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Бездєнєжних Наталія Олександрівна
Кунська Любов Миколаївна
Лук'янова Наталія Юріївна
Налєскіна Леся Анатоліівна
Стеблянко Тамара Ісаківна
Чехун Василь Федорович

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2020-04-02