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Information × Registration Number 0211U005871, 0110U005761 , R & D reports Title The research of genetic backgrounds and influence of environmental factors on realization of genetic predisposition to cancer development popup.stage_title Head Buchynska Lyubov Georgiyivna, Доктор біологічних наук Registration Date 13-12-2011 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The human papillomavirus infection types 16 and 18 was detected in 27,5% of endometrial cancer and 15,3% of ovarian cancer. The presence of DNA of human papillomavirus in tumor tissues of endometrium and ovary correlated with diffuse or focal expression of human papillomavirus oncoprotein E6. Expression of tumor suppressor protein p53 was significantly lower in E6-positive endometrial and ovarian carcinomas compared to E6-negative tumors. Thereby human papillomavirus infection in endometrial and ovarian carcinomas associated with E6 oncoprotein expression and reduction of p53 that indicate about inhibition of p53 suppressor function and alteration of proliferation control. Product Description popup.authors Білик Олена Олександрівна Брєєва Ольга Володимирівна Буднікова Дарія Володимирівна Бучинська Любов Георгієвна Глущенко Надія Миколаївна Дьоміна Емілія Анатоліївна Несіна Ірина Петрівна Юрченко Наталія Петрівна popup.nrat_date 2020-04-02 Close