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Information × Registration Number 0211U005873, 0110U005771 , R & D reports Title Construction of cancer vaccines based on tumor cells and hest shock proteins popup.stage_title Head Potebnya Grygory Platonovych, Registration Date 13-12-2011 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The dynamics of heat shock proteins expression in the tumor (Guerin carcinoma in rats and Ehrlich carcinoma and Lewis lung carcinoma in mice) was investigated in terms of local microwave hyperthermia for increase of tumor cells antigenicity. Using the method of SDS-electrophoresis it was shown the difference between the protein spectra of tumors extracts that were exposed to hyperthermia and without it, namely, significant increase in the proportion of proteins with MM about 70 kDa, 80 kDa and 10 kDa. The technology of cancer vaccine production based on tumor cells, enriched with HSP-70, by various products of bacterial synthesis was developed. conducted The screening studies of their effectiveness in vivo was performed on model tumors (Ehrlich carcinoma and Lewis lung carcinoma). It was found that the effectiveness of vaccines, constructed on the basis of tumors subjected to hyperthermia for heat shock protein enrichment, exceeds the efficacy of vaccines produced by traditional technology. Product Description popup.authors Бубновська Лариса Микитівна Воєйкова Ірина Михайлівна Ганусевич Ірина Іванівна Гуменюк Лілія Дмитрівна Діденко Геннадій Васильович Дідківська Лідія Павлівна Караман Ольга Михайлівна Ковельська Антоніна Василівна Кузьменко Олександр Петрович Лісовенко Галина Степанівна Мамонтова Леся Анатоліївна Потебня Григорій Платонович Сергієнко Тетяна Карлівна Шпак Євгеній Григорович popup.nrat_date 2020-04-02 Close