Search academic texts

Information × Registration Number 0211U005909, 0111U004920 , R & D reports Title Study of molecular mechanisms of action of angucycline antibiotic landomycin E popup.stage_title Head Panchuk Rostyslav Ruslanovych, Registration Date 15-12-2011 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 It is shown that landomycin Е possesses principally different mechanism of anticancer action towards tumor cells in comparison to structurally similar drug doxorubicin, which is already used in clinics. In particular, landomycin E blocks tumor cells in G1-phase of cell cycle, and this process is mediated via reactive oxygen species. The key target of landomycin E is effector apoptotic enzyme caspase-7. This unique mechanism of action allow landomycin E to effectively kill tumor cells, even if they are deficient by key apoptotic enzymes, such as caspase-3. Thus, taking into consideration significant antineoplastic potential of landomycin E and its unique mechanism of action, this antibiotic can be used as second line defense drug during treatment of cancer patients. The achieved results were published in 1 article and 5 conference thesis Product Description popup.authors Панчук Ростислав Русланович popup.nrat_date 2020-04-02 Close