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Information × Registration Number 0211U005955, 0111U008869 , R & D reports Title Synthesis and biomedical researches of macrobicyclic complexes as topological inhibitors of vital enzymes, RNK polymerase, DNA topoisomerase, HIV protease for diagnosis and therapy. popup.stage_title Head Varzatskii Oleg Anatolievich, Registration Date 21-12-2011 Organization National Academy of Scienіses of Ukraine, Council of Productive Forces Studies of Ukraine popup.description2 Report on NDR: 38 p., 9 fig., 1 table., 34 literary sources.The row of clathrochelates of iron( II) was synthesized, their physical and chemical properties was investigated, set structure and bilding of structure, research of biological activity is conducted in the processes of transcription: namely inhibity of RNA- polimeraze T-7 and topoizomeraza-1 in vitro. It is set that research complexes find out extraordinarily high ingibiruyuschuyu activity in relation to RNK- to polimeraze of T-7 and nonactive in relation to topoizomeraze-1. This is firts investigation of biological activity of clatrochelates, the new type of inhibitors of transcription is found, that gives an occasion to expect anti viral and anti tumour activity of this compounds. Product Description popup.authors Варзацький О. А. Денисенко І.М. Третякова І.М. Федосова Н.М. Черній В. Я. Шульга С.В. popup.nrat_date 2020-04-02 Close
R & D report
Synthesis and biomedical researches of macrobicyclic complexes as topological inhibitors of vital enzymes, RNK polymerase, DNA topoisomerase, HIV protease for diagnosis and therapy.
Head: Varzatskii Oleg Anatolievich. Synthesis and biomedical researches of macrobicyclic complexes as topological inhibitors of vital enzymes, RNK polymerase, DNA topoisomerase, HIV protease for diagnosis and therapy.. (popup.stage: ). National Academy of Scienіses of Ukraine, Council of Productive Forces Studies of Ukraine. № 0211U005955
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Updated: 2026-03-25


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