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Registration Number

0211U005985, 0111U007771 , R & D reports

Title

Mechanisms of cytotoxic activity of angucycline antibiotic landomycin E towards tumor cells

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Head

Stoika Rostyslav Stepanovych,

Registration Date

21-12-2011

Organization

Institute of cell biology, National Academy of Sciences of Ukraine

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Antineoplastic affect of angucyline antibiotic landomycin E has been studied on 6 various tumor cells lines, possesing 5 different resistancy mechanims towards 4 anticancer drugs-mitoxantrone, oxaliplatin, cisplatin and doxorubicin. In all cases we haven't observed any significantly increased resistance of these cell lines towards landomycin E compared to wild type parental cells. It is shown that landomycin Е possesses principally different mechanism of anticancer action towards tumor cells in comparison to structurally similar drug doxorubicin, which is already used in clinics. In particular, landomycin E blocks tumor cells in G1-phase of cell cycle, and this process is mediated via reactive oxygen species. The key target of landomycin E is effector apoptotic enzyme caspase-7. This unique mechanism of action allow landomycin E to effectively kill tumor cells, even if they are deficient by key apoptotic enzymes, such as caspase-3. Thus, taking into consideration significant antineoplastic potential of landomycin E and its unique mechanism of action, this antibiotic can be used as second line defense drug during treatment of cancer patients. The achieved results were published in 1 article and 1 conference thesis

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Антонюк Володимир Олександрович
Бойко Наталія Миколаївна
Кіт Юрій Ярославович
Панчук Ростислав Русланович