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Information × Registration Number 0211U006097, 0110U002251 , R & D reports Title Investigating significance of a clinical manifestations, morfological and biochemical features of the malignant cells for diagnostics, course prognosis and treatment results optimization in hairy cell leukemia popup.stage_title Head Loginsky Volodymyr Eustakhovych, Доктор медичних наук Registration Date 18-02-2011 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 The main clinical manifestations of HCL were splenomegaly and anemia syndrome (100% and 70% of patients, respectively) on a background of significant leukopenia. Among the lymphocytes in blood, population of tartrat-resistant acidic phosphate "hairy" cells was found (except 3 cases). It was stated a suppression of normal hematopoiesis, diffuse infiltration by lymphoid cells, mainly "hairy" (61.7%) and reticulin fibrosis in the bone marrow. The immunоphenotypic signs of HCL tumor substrate were shown. There are B-cell population (CD19+, CD20+, CD22+) with high expression of CD25, CD11c and CD103 markers in the absence of CD5 and CD23. In all HCL patients a very high level of residues, specific to O-glycosides (Thomsen-Fridenreichs antigen, PNA lectin), were identified on >60% cells. HCL spleen cells have a similar lectin phenotype with reduced lectin RCA binding. The standard cytogenetic method showed the association of HCL with a cytogenetic abnormality - del(17)(p13) in one case. In all examined HCL patients (6 persons) no lupus anticoagulant was found. Product Description popup.authors Євстахевич Ю.Л. Барілка В.А. Виговська Я.І. Зотова О.В. Красівська В.В. Лебедь Г.Б. Лещук О.В. Логінський В. Є. Лук'янова А.С. Мазурок А.А. Пеленьо Н.В. Примак С.В. Римар М.М. Цяпка О.М. Шалай О.О. Ясниський З.І. popup.nrat_date 2020-04-02 Close