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Information × Registration Number 0211U006106, 0110U004648 , R & D reports Title Optical sensor systems based on nanostructured molecularly imprinted polymer membranes for environmental monitoring and medical diagnostics popup.stage_title Head Sergeyeva Tetyana Anatoliivna, Доктор медичних наук Registration Date 07-11-2012 Organization Institute of Molecular Biology and Genetics popup.description2 Using the method of molecular imprinting polymer membrains containing nano-sized binding sites capable of selective recognition of both micotoxins affiliated to aflatoxins and phenols were synthesized. For the first time nanostructured molecularly imprinted polymer membranes synthesized in situ were used as sensitive elements of optical biosensors for phenols and aflatoxins detection. The analytical systems for phenols and aflatoxins detection based on nanostructured molecularly imprinted membranes provide highly-selective and sensitive detection of the analytes (detection limits for different biosensors comprise 1-50nM), which is comparable to detection limits of ELISA and immunosensor devises. At the same time, stability of the biosensors based on nanostructured polymers is significantly (up to 100 times) higher as compared to the biosensors based on natural receptors and enzymes. The structure of the nano-sized receptor site in the molecularly imprinted polymer membranes was predicted and optimized using the methods of computational modeling. Using the methods of computational modeling, the synthetic binding sites with the desired properties (high selectivity or groop selectivity towards toxic molecules) were synthesized. The possibility of application of the designed sensor systems for aflatoxin and phenol analysis in both model and real samples was demonstrated. Product Description popup.authors Білоіван О.А. Бубряк О.А. Калініченко Л.О. Сергеєва Т.А. Солдаткін О.П. Стадник О.Л. popup.nrat_date 2020-04-02 Close