Search academic texts

Information × Registration Number 0211U006241, 0108U010547 , R & D reports Title Revealing the potential molecular markers of B-cell non-Hodgkin's lymphomas progression popup.stage_title Head Sidorenko Svetlana Pavlivna, Registration Date 02-03-2011 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The expression of CD150, CD27, CD38, PKC beta II, PKD2, pPKD2, Bcl6 and IRF4 was evaluated in different subpopulations of human B cells. It was shown that PKD1 and PKD2, but not the PKD3, are controlling the basal level of Akt phosphorylation. It has been revealed that CD150 is involved in the regulation of IRF4 expression levels. Moreover, silencing of translation via miRNA expression may play the important role in this process. The found heterogeneity of diffuse large B cell lymphoma in PKC beta II, рPKD2, Bcl-6, IRF4 та СD27 expression may serve as the basis for further studies of tumor prognosis factors. Our studies showed that PKC beta II, рPKD2, CD38, CD27, IRF4, p53 and IPO-38 could be used as a potential markers for the evaluation of individualization of small lymphocytic lymphoma prognosis. Product Description popup.authors Бердова Ганна Григорівна Ковалевська Лариса Миколаївна Міхалап Світлана Віталіївна Сидоренко Світлана Павлівна Шабельник Мар'яна Юріївна Шлапацька Лариса Миколаївна Юрченко Марія Юріївна popup.nrat_date 2020-04-02 Close