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Information × Registration Number 0211U006243, 0106U005545 , R & D reports Title To determine the role of the nitric oxide radical forms and superoxide radical-anions in the progression of the human malignant tumors and the prognosis of the disease course popup.stage_title Head Sidorik Evgeniy Petrovich, Registration Date 02-03-2011 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The role of oxygen radicals (radical oxygen species)-superoxide radical-anions and nitric oxide radical forms generated by the mitochondria of tumor cells and blood neutrophils has been determined in the degradation in intercellular matrix and vascularization that promotes invasion and metastasis of human breast and gastric malignant tumors. In the formation of cellular hypoxia in tumor tissue revealed patterns that occur in the formation of FeS-NO complexes and activation of matrix metalloproteinases - MMP-2, MMP-9. These indices can be used as markers of prognosis and treatment optimization. Product Description popup.authors Бурлака Анатолій Павлович Лукін Сергій Миколайович Мельников Олег Ростиславович Момот Валентина Яківна П'ятчаніна Тетяна Віталіївна Сидорик Євгеній Петрович popup.nrat_date 2020-04-02 Close